Universal CAR-NK cells derived from induced pluripotent stem cells made from umbilical cord blood for oncoimmunotherapy of immediate availability
Principal Investigator
Belen Alvarez
File
PI21/00796
Duration
2022-2025
Funded by
Instituto de Salud Carlos III
Funded by the Carlos III Health Institute and co-funded by the European Union through FEDER funds.
Objective
To produce NK from induced pluripotent stem cells (iPSC) made from 'super donors' naturally homozygous for broadly compatible HLA haplotypes (haplolines), thus developing large-scale production of CAR-NK with immediate availability and minimized graft rejection and covering a large part of the population.